(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
- Product Name
- (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
- CAS No.
- 173897-44-4
- Chemical Name
- (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride
- Synonyms
- Y-33075 HCl;Y-33075 2HCl;Y 39983 2HCL;Y 39983, 2 HCl salt;Y39983 HYDROCHLORIDE;Y39983 dihydrochlortide;Y-33075 (dihydrochloride);(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride;Y33075 dihydrochloride,ROCK,Y33075,Y 33075,ROK,Rho-associated kinase,Inhibitor,Rho-associated protein kinase,Y 33075 dihydrochloride,Rho-kinase,inhibit,Y-33075
- CBNumber
- CB32554140
- Molecular Formula
- C16H18Cl2N4O
- Formula Weight
- 353.24632
- MOL File
- 173897-44-4.mol
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
N-Bromosuccinimide Price
- Product number
- A594890
- Product name
- Y-39983Hydrochloride
- Packaging
- 2.5mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0096
- Product name
- Y-33075dihydrochloride
- Purity
- 97.34%
- Packaging
- 10mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- B1176
- Product name
- Y-39983dihydrochloride
- Packaging
- 10mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- KIN0002446
- Product name
- (R)-4-(1-AMINOETHYL)-N-(1H-PYRROLO[2,3-B]PYRIDIN-4-YL)BENZAMIDE DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.43
- Updated
- 2021/12/16
- Product number
- CS-0096
- Product name
- Y-33075dihydrochloride
- Purity
- 97.34%
- Packaging
- 5mg
- Price
- $144
- Updated
- 2021/12/16
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Chemical Properties,Usage,Production
Uses
Y-39983 Hydrochloride contain Rho kinase inhibitory activity.
Biological Activity
y-39983 dihydrochloride is a novel and selective inhibitor of rock family with ic50 value of 3.6nm for rock [1].y-39983 dihydrochloride has shown a selective inhibitor of rho-associated coiled coil-forming protein kinase( rock ) with ic50 values of 3.6nm, 0.42μm and 0.81μm for rock, pkc and camkii, respectively [1]. apart from these, y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. in addition, y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry [2]. moreover, y-39983 lowered the intraocular pressure ( iop) in a dose-dependent fashion in the eyes of rabbits and monkeys [1].
References
[1] tokushige h1, inatani m, nemoto s, sakaki h, katayama k, uehata m, tanihara h. effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. invest ophthalmol vis sci. 2007 jul;48(7):3216-22.
[2] watabe h1, abe s, yoshitomi t. effects of rho-associated protein kinase inhibitors y-27632 and y-39983 on isolated rabbit ciliary arteries. jpn j ophthalmol. 2011 jul;55(4):411-7. doi: 10.1007/s10384-011-0048-9. epub 2011 jun 11.
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride Suppliers
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